Nans Products

Nans Products is a pioneer in the manufacturing and exporting of high-quality Diosmin-based products in India. Diosmin, a naturally occurring flavonoid found in citrus fruits or derived semi-synthetically from hesperidin, is known for its diverse therapeutic properties and extensive applications.

Brief History: Discovered in 1925 from Scrophularia nodosa, Diosmin was introduced as a therapeutic agent in 1969. Over the past 30 years, it has been widely recognized for its role in vascular health as a phlebotonic and vascular-protecting agent. Recent studies are also exploring its potential benefits in treating conditions such as cancer, premenstrual syndrome, colitis, and diabetes.

Pharmacokinetic Effects: Diosmin acts as a potent vascular-protecting agent, effectively used in the treatment of chronic venous insufficiency, hemorrhoids, lymphedema, and varicose veins. As a flavonoid, Diosmin exhibits anti-inflammatory, free-radical scavenging, and antimutagenic properties. It undergoes rapid transformation by intestinal flora into diosmetin, which is then absorbed and distributed throughout the body. Diosmin or diosmetin not absorbed is excreted through urine or feces.

Inflammation, Microcirculation & Capillary Permeability: The mechanisms of Diosmin include enhancing venous tone, improving lymphatic drainage, protecting microcirculation in capillary beds, inhibiting inflammatory reactions, and reducing capillary permeability. It inhibits prostaglandin E2 (PGE2) and thromboxane A2 (TxA2), and also suppresses leukocyte activation, migration, and adhesion, thereby safeguarding against microcirculatory damage.

Applications:

• Chronic Venous Insufficiency, Hemorrhoids, Varicose Veins: Diosmin-containing formulations effectively alleviate symptoms associated with chronic venous insufficiency, including pain, swelling, and cramps. They are also beneficial in treating severe stages like venous ulceration.
• Lymphedema: Diosmin enhances lymphatic flow and oncotic pressure, significantly aiding in conditions of lymphedema induced by injuries or burns.
• Diabetes: Studies indicate Diosmin's role in managing diabetic complications by improving glucose levels, antioxidant activity, and hemorheological parameters, thereby reducing stasis and ischemia.
• Dermatological, Menstrual & Wound Healing: Diosmin shows promising results in managing conditions such as stasis dermatitis, wound healing, premenstrual syndrome, and dermatofibrosclerosis, indicating its diverse therapeutic potential.

Drug-Nutrient Interactions: Caution is advised when combining Diosmin with blood-thinning medications like aspirin, due to its potential to decrease blood viscosity. It may also influence cytochrome P450-mediated metabolism, affecting the pharmacokinetics of concurrent medications.

Side Effects and Toxicity: Extensive studies have shown Diosmin to be safe, with no mutagenic activity, embryo toxicity, or significant impact on reproductive function observed in animal models. It exhibits minimal adverse effects and no documented cases of acute or chronic toxicity.

For inquiries about our superior Diosmin products or to place an order, please contact our sales team. Nans Products adheres to stringent quality standards and employs advanced manufacturing processes to deliver Diosmin derivatives of exceptional quality and efficacy.